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Meet the billionaire scientist couple who invented Pfizer’s COVID-19 vaccine

DUBAI: News that a Pfizer vaccine is 90% effective against COVID-19 has been hailed as a “miracle”. In the race against time, the announcement signalled that the fight against the virus is now turning in man’s favour.

On Monday, following the vaccine breakthrough report, the company’s stock price went ballistic, along with oil prices. Airline stocks soared, too, on hopes the world will start flying again.

Husband-and-wife team

The science behind it, however, is the work of BioNTech. The brains behind the company is a husband-and-wife team of researchers: Ugur Sahin, 55, and Ozlem Tureci, 53, founders based in the German city of Mainz. Their extraordinary lab work, done in anonymity, goes back many years. The rapid progress of their candidate vaccine, BNT162, has now shot them to global recognition.

The brains behind the Pfizer COVID-19 vaccine is a husband-and-wife team of researchers: Ugur Sahin, 55, and Ozlem Tureci, 53, founders who based in the German city of Mainz.
Image Credit: Facebook

In the past, they focussed on developing cancer therapies, essentially by programming cells to produce therapeutic proteins. For a decade, their company had never brought a product to market. During a 2018 conference of infectious disease experts in Berlin, Prof. Sahin made a bold statement: that his company might be able to use its “messenger RNA technology” to rapidly develop a vaccine in the event of a global pandemic.

That prediction is panning out now. The couple dedicated their lives in tireless work to push cancer vaccines. Today, they are hailed as the key scientists that could potentially help mankind neutralise the corovirus that has so far left 1.27 million people dead and 51.5 million infected. BioNTech is leveraging Pfizer’s clinical trial, marketing, manufacturing prowess. Its alliance with China’s Fosun Pharma gives it a good shot of the mainland market, too.

94 patients
On November 9, 2020 a first look into the data gleaned from 94 patients showed a “critical milestone” was hit. Pfizer did not give a breakdown of how many of those who fell ill received the vaccine. However, over 90% effectiveness implies that no more than 8 of the 94 people who caught COVID-19 had been given the experimental vaccine.

Immunotherapy expert

Born on September 19, 1965 in Iskenderun, Turkey, Dr Sahin is a physician and immunologist. When he was 4, his family moved to Cologne, Germany. His parents worked at a Ford plant. He grew up dreaming to be a doctor, and became a physician at the University of Cologne. In 1993, he earned a doctorate from the university for his work on immunotherapy in tumor cells. He is the chief executive and co-founder of biotech company BioNTech.

Ugur Sahin (right), 55, and Ozlem Tureci, 53, founders based in the German city of Mainz. Their vaccine is unlike any other out in the market today. While administered like other vaccines — via an intramuscular injection — it contains an anti-viral messenger RNA.
Image Credit: BioNTech

Dr Tureci is the daughter of a Turkish physician who immigrated to Germany from Istanbul. Born in 1967 in Lastrup, Germany, she first wanted to be a nun, wound up in a medical school and became one of Germany’s pioneering research scientists. She is currently the chief medical officer of BioNTech.

On the day they were married, Dr. Sahin and Dr. Tureci returned to the lab after the ceremony, according to a New York Times report. The pair was initially focused on research and teaching, including at the University of Zurich, where Dr. Sahin worked in the lab of Rolf Zinkernagel, who won (together with Australia’s Peter C. Doherty) a Nobel Prize in 1996 in medicine for the discovery of how the immune system recognises virus-infected cells.

Lightspeed
BioNTech launched its project called “Lightspeed” in mid-January 2020. The objective was to develop a vaccine against the coronavirus. The US government, meanwhile, called its accelerated vaccine development “Warpspeed.” Vaccines usually takes many years to develop.
In mid-November BioNTech and its US partner, Pfizer, plan to apply for emergency-use approval in the US. Interim data released on Monday show the vaccine is 90% effective in inducing immunity to the coronavirus. If the report is validated by the US FDA review board, this would put the Pfizer-BioNTech and China’s Fosun well ahead in the vaccine race.

In 2001, the couple founded Ganymed Pharmaceuticals, which developed drugs to treat cancer using monoclonal antibodies. In 2008, they founded BioNTech, with the aim of using a wider range of technologies, including messenger RNA, to treat cancer. “We want to build a large European pharmaceutical company,” Dr. Sahin said in an interview with the Wiesbaden Courier, a local paper. They sold Ganymed for $1.4 billion in 2016.

Even before the pandemic, BioNTech was abuzz with research activity, and raised hundreds of millions of dollars. It currently has more than 1,800 staff, with offices in Berlin, other German cities and Cambridge, Massachusetts. 

FILE PHOTO: The headquarters of German biotech firm BioNTech is photographed in Mainz, Germany, September 17, 2020.
Image Credit: REUTERS/Kai Pfaffenbach/File Photo

In 2018, it began a partnership with Pfizer. Last year, the Bill & Melinda Gates Foundation invested $55 million to fund its work treating HIV and TB. Also in 2019, Dr. Sahin was awarded the Mustafa Prize, a biennial Iranian prize for Muslims in science and technology. In June 2020, BioNTech received $250 million from Singapore’s Temasek Holdings and other investors through a private placement of mandatory convertible bonds.

Clinical trial

The Pfizer-BioNTech vaccine is unlike any other out in the market today. While administered like other vaccines — via an intramuscular injection — it contains an anti-viral messenger RNA. This technique has never been deployed in the past against any disease.

The mRNA vaccine injects synthetic genes “programmed” to use the human body’s own proteins to generate “fake” viruses similar to a target pathogen (like SARS-CoV-2) — which then trigger a response from our own immune system.

90% EFFECTIVE, BASED ON INITIAL DATA: News erupted on Monday (November 9, 2020) about the first reading of Phase-3 trial data of the candidate COVID-19 vaccine from Pfizer Inc. The New York-based pharma giant announced that its experimental vaccine was more than 90 per cent effective in preventing COVID, based on an interim data analysis. Pfizer earlier announced its price for the vaccine at $19.50 based on an advanced US government contract, contingent on the vaccine proving effective in clinical trials.
Image Credit: Reuters

A tried-and-tested technique in making vaccines is to use virus particles that are partly alive (attenuated), similar to the smallpox vaccine invented by Dr Edward Jenner in the UK in 1796, or “killed” (inactivated), similar to the hepatitis, polio and flu shots currently in use. But this method takes time.

The untested mRNA, on the other hand, has one big plus: it reduces vaccine development into a software. This allows mRNA shots to be generated and manufactured in weeks, and produced at scale more rapidly than conventional vaccines.

Synthetic genes

mRNA vaccines had been under development since the 1990s. It essentially “trains” the human body to produce the antibodies necessary to fight the real virus when a person gets infected. As a vaccine development platform, mRNA is a relatively quick and inexpensive way to mass produce vaccines, and is theorically safer too, as it doesn’t use live or killed versions of the virus used in vaccine platforms in use today.

The shorter manufacturing times, safety and potential efficacy of mRNA vaccines could make a huge impact on public health — and revenues. Pfizer and BioNTech could, together, generate $13 revenues from the coronavirus vaccine, according to some estimates.

US pharmaceutical giant Pfizer and German biotech firm BioNTech had on Monday announced that their COVID-19 vaccine candidate is over 90% effective based on initial data from a large study. The companies are the first to show successful data from a large-scale clinical trial for the vaccine. Behind this early success is a Turkish immigrant husband-wife duo: Ugur Sahin and Oezlem Tuereci.
Image Credit: BioNTech

On July 22, 2020, the US government placed an initial order with Pfizer of 100 million doses for $1.95 billion, with an option to acquire up to 500 million additional doses for the US. The European Union also signed contracts to supply 200 million doses of a SARS-CoV-2 vaccine for the EU, 30 million doses for the United Kingdom, and 120 million doses for Japan if proven safe.

Protection

Pfizer’s COVID-19 vaccine, called BNT2b2, underwent trials in the US and China. On May 4, 2020, the first patient enrolled in Pfizer’s vaccine trial was given the shot at the University of Maryland School of Medicine in Baltimore. Volunteers and vaccinators had no clue as whether they were being injected with a real dose (experimental vaccine) or a placebo (control) made of saline solution.

Eventually, some 40,000 people took part in the trial — a “double-blind”, randomised, placebo-controlled experiment. A statement released October 16, 2020 (Friday) suggested the company’s coronavirus vaccine candidate could be ready for distribution throughout the US by end-November.

No family car

On Tuesday, November 10, 2020, the value of their company BioNTech soared to $21 billion in the wake of the vaccine news. As such Prof. Sahin and Dr. Tureci are now among the 100 richest Germans. The two billionaires live with their teenage daughter in a modest apartment near their office. Each morning, they pedal to work in Mainz. They do not own a car.

VACCINE MAKER: Another vaccine maker using the mRNA platform is Moderna, a Massachusetts-based biotech company, now also in advanced Phase-3 trials of its COVID-19 vaccine. Though yet unproven, mRNA vaccines had been under development since the 1990s. It essentially “trains” the human body to produce the antibodies necessary to fight the real virus when a person gets infected. As a vaccine development platform, mRNA is a relatively quick and inexpensive way to mass produce vaccines, and is theorically safer too, as it doesn’t use live or killed versions of the virus used in traditional vaccine platforms. mRNA-based vaccines could make a huge impact due to their shorter manufacturing times and potential efficacy.
Image Credit: Facebook
Scientific advisory board
BioNTech has been supported by a scientific advisory board under the direction of Rolf M. Zinkernagel, a professor of immunology at the University of Zurich. Dr Zinkernagel and Dr Peter Doherty are credited for their breakthrough discovery on the understanding of how the immune system recognizes virus-infected cells.

Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses can’t reproduce. Zinkernagel and Doherty won the 1996 Nobel Prize for medicine for their discovery of how killer T-cells work.

They showed that in order for killer T-cells to recognise infected cells, they had to recognise two molecules on the surface of the cell — not only the virus antigen (a protein encoded by the viral genome), but also a molecule of the major histocompatibility complex (MHC).

This recognition was done by a T-cell receptor on its cell surface. The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too.